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Novel analysis method organizes genomic cancer data

The technology that allows scientists to profile the entire genome of individual tumors offers new hope for discovering ways to select the best treatment for each patient's particular type of cancer....

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Potential for incorrect relationship identification in new forensic familial...

New research suggests that unrelated individuals may be mistakenly identified as genetic family members due to inaccurate genetic assumptions. This is particularly relevant when considering familial...

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Researchers excel in predicting cancer drug sensitivity

Researchers from Helsinki Institute for Information Technology HIIT and Institute for Molecular Medicine Finland FIMM have developed a triumphant solution for predicting responses of breast cancer...

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Risk of childhood obesity can be predicted at birth

A simple formula can predict at birth a baby's likelihood of becoming obese in childhood, according to a study published today in the open access journal PLOS ONE.

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K9 osteosarcoma samples identify drivers of metastasis in pediatric bone cancer

Human osteosarcoma samples are hard to come by, making the disease difficult to study. However, K9 bone cancer is genetically indistinguishable from the human form of the disease, and over 10,000...

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Forensic familial search methods carry risk of certain false matches

Forensic DNA-based familial search methods may mistakenly identify individuals in a database as siblings or parents of an unknown perpetrator, when in fact they are distant relatives, according to...

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Major cancer genotyping study logs 5,000th tumor profile

More than 5,000 genetic profiles of tumor DNA have been completed in a large research study by scientists at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital...

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Functional genetic variation in humans: Comprehensive map published

European scientists, led by researchers from the University of Geneva (UNIGE)'s Faculty of Medicine in the context of the GEUVADIS project, today present a map that points to the genetic causes of...

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Blood test might help guide pancreatic cancer treatment

(HealthDay)—A simple blood test might help predict a pancreatic cancer patient's chances of benefiting from chemotherapy, a small study suggests.

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Ganetespib shows potency against ALK-positive lung cancer and overcomes...

A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small...

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Genetics might determine which smokers get hooked, research says

Researchers have identified genetic risk factors that may accelerate a teen's progression to becoming a lifelong heavy smoker.

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Legal levels of atrazine alter neuroendocrine, reproductive genes in zebrafish

(Medical Xpress)—A Purdue University study found an agricultural herbicide alters reproductive and neuroendocrine genes during embryonic development in fish, a finding that will help establish a...

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Virus-like particles provide vital clues about brain tumors

Exosomes are small, virus-like particles that can transport genetic material and signal substances between cells. Researchers at Lund University, Sweden, have made new findings about exosomes released...

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Computer algorithms help find cancer connections

Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer. In a study reported today in the New England...

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Scientists assemble genetic playbook for acute leukemia

A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood...

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Breast cancer heterogeneity no barrier to predictive testing, study shows

Breast cancers contain many different cell types with different patterns of gene expression, but a new study provides reassurance that this variability should not be a barrier to using gene expression...

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Genetic variations associated with susceptibility to bacteria linked to...

Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter pylori, a bacteria that is a major cause...

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First prospective trial shows molecular profiling timely for tailoring therapy

A clinical trial has shown that patients, and their physicians, are eager to jump into next-era cancer care—analysis of an individual's tumor to find and target genetic mutations that drive the cancer....

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Epigenetic factor likely plays a key role in fueling most common childhood...

(Medical Xpress)—Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL),...

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Early warning of newborn withdrawal

In substance-exposed newborns, identification of the gene variations associated with risk of opioid addiction could aid the treatment of their withdrawal symptoms in the critical hours after birth,...

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